Adeno-associated viruses (AAVs) are versatile vectors serving as the leading platform in gene therapy.
In this webinar, Prof. Dr. Susumu Uchiyama will provide an overview of today’s state-of-the art analytical methods for AAV characterization and address key parameters to monitor during process development in AAV manufacturing. Prof. Uchiyama will discuss the rationale behind selecting individual methods for each quality attribute explaining how these analytical approaches contribute to the optimization of the manufacturing process and the assurance of product quality.
Subsequently, Dr. Melanie Schwerdtfeger will present case studies highlighting the measurement of AAV infectivity and the full-to-empty capsid ratio by orthogonal methods such as analytical ultracentrifugation and mass photometry as part of drug product development.
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