Could Transmucosal Delivery Be the Right Route for Your API?

API requirements for transmucosal delivery, Mucofilm compatibility and key development steps from feasibility through to commercial manufacture.
September 10th, 2025
16:00 (CET) / 10am (ET)
OVERVIEW

Transmucosal drug delivery has advanced significantly over recent decades—from simple liquid formulations to sophisticated mucoadhesive buccal films. Today, technologies such as Mucofilm® provide an effective solution for APIs with poor oral bioavailability, sensitive degradation profiles, or a need for rapid onset of action.

This webinar will explore the regulatory, scientific, and practical considerations of buccal drug delivery systems. You’ll gain insight into how bypassing first-pass metabolism via the oral mucosa can improve therapeutic efficacy, reduce the required dose, and enhance patient compliance—particularly in populations such as children or those with swallowing difficulties.

 

We will guide you through the development journey of a transmucosal film—from initial permeability testing using models such as Franz cells with porcine mucosa, to prototype assessment and full product development. You’ll also learn what to look for in a trusted CDMO partner specialising in this highly targeted delivery platform.

 

Mucofilm® is a proven, flexible technology that enables fast-track feasibility assessments. This session will highlight how AdhexPharma’s experience supports early decision-making—helping you determine whether transmucosal delivery is the right route for your compound, before significant resources are committed

Addressed Challenges

01Identifying APIs with low oral bioavailability that could benefit from buccal administration via Mucofilm® to bypass first-pass metabolism and improve efficacy. 
02Finding a CDMO with proven expertise in mucoadhesive buccal film development, manufacturing, and the regulatory requirements specific to this delivery platform. 
03Completing robust feasibility assessment quickly enough to inform go/no-go decisions before significant formulation or clinical development resources are committed. 
04Determining transmucosal suitability early in development when permeability, stability, and mucosal compatibility data are still limited or unavailable. 

WHAT YOU WILL LEARN

01Understand the API characteristics that make a compound a strong candidate for transmucosal delivery, including permeability, molecular weight, and stability profile. 
02Learn how to assess compatibility with the Mucofilm® technology platform, from initial permeability testing through to prototype evaluation and full development. 
03Gain insight into the key development and manufacturing steps for Mucofilm-based products, from concept through to commercial-scale production readiness. 
04Understand how AdhexPharma's fast-track feasibility process supports early decision-making and reduces risk before significant development investment is made. 
Reserve Your Seat
SPEAKER
Transmucosal drug delivery webinar
Marion Tegelkamp
Head of CMC and corp. QC, Labtec GmbH
Head of CMC & Corporate QC at Labtec (AdhexPharma Group) with 20+ years of experience in analytical development, skin permeation, quality control, and regulatory compliance. I joined Labtec in 2002 and have since led analytical departments in Langenfeld and Hamburg, serving as Head of QC from 2015 to 2025. Since 2024, I’ve also overseen galenic development. My focus is now on strategic development in Galenics, Analytics, Business Development, IP, and QC harmonisation across the group, while supporting central development and infrastructure projects.
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